Image is an illustration, may not reflect the exact product sold.


Other products by Merck

Merck - 5.08774.0001 - Apoptosis Activator VIII, TP421 - Calbiochem

  • MFR SKU: 5.08774.0001
  • ITEM #: 17952824
  • 0 Reviews / 0 Questions
$261.50
Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 17952824
A cell-permeable inhibitor of cancer cell proliferation (IC = 400, 500, 800 nM HPAC, MIA, and PaCa-2 cells, respectively). Arrests cell cycle at G0/G1 phase and reduces autophagy.
This listing is for 10 mg Glass bottle

Merck - 5.08774.0001 - Apoptosis Activator VIII, TP421 - Calbiochem

  • Item #: 17952824
  • MFR SKU: 5.08774.0001
  • Overview A cell-permeable triphenylphosphonium compound that exhibits selective toxicity towards cancer cells and inhibits their proliferation (IC 50 = 400, 500, 800 nM and 1.1. µ M for HPAC, MIA PaCa-2, BxPC-3, and PANC-1 pancreatic cancer cells, respectively). Arrests cell cycle at G0/G1 phase of the cell cycle in a time- and dose-dependent manner. It accumulates in mitochondria and induces mitochondrial and cytosolic accumulation of reactive oxygen species. Induces apoptosis by activating caspase-8 and 7 and by lowering the levels of Bcl-2 and survivin in cancer cells. Reduces autophagy as evidenced by a reduction in beclin-1 and increase in LC3B-II and p62 levels (at ~20 µ M). Also shown to diminish Src phosphorylation (Tyr416) correspondingly reduce in Ser576 and Tyr861 phosphorylation in focal adhesion kinase (FAK).
  • Please note that the molecular weight for this compound is batch-specific due to variable water content.
  • Catalogue Number 508774
  • Brand Family Calbiochem®
  • Synonyms (2-(7-(Diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)triphenylphosphonium Salt
  • References Millard, M., et al. 2013. PLos One. 5, e13131.
  • Form Yellow powder
  • Hill Formula CHNOP+Br-.HO
  • Chemical formula CHNOP+Br-.HO
  • Quality Level MQ100 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 400 nM
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

There are no questions about this product yet. Be the first to ask a question.

0 out of 5 stars
5 Star
0 %
4 Star
0 %
3 Star
0 %
2 Star
0 %
1 Star
0 %

Review this product

Tell us about your personal experience

Recently Viewed Items