Image is an illustration, may not reflect the exact product sold.


Other products by Merck

Merck - 5.09106.0001 - Sphingosine Kinase-2 Inhibitor, K145 - Calbiochem

  • MFR SKU: 5.09106.0001
  • ITEM #: 17952913
  • 0 Reviews / 0 Questions
$353.00
Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 17952913
A cell permeable, selective, sphingosine competitive inhibitor of spingosine Kinase -2 (IC = 4.3 µM).
This listing is for 10 mg Glass bottle

Merck - 5.09106.0001 - Sphingosine Kinase-2 Inhibitor, K145 - Calbiochem

  • Item #: 17952913
  • MFR SKU: 5.09106.0001
  • Overview A cell permeable, orally bioavailable thiazolidine-2, 4-dione derivative that acts as a selective, sphingosine competitive inhibitor of spingosine Kinase -2 (SphK2; IC 50 = 4.3 µ M; Ki = 6.4 µ M), but does not affect the activities of sphingosine kinase-1, ceremide kinase, and ceramide synthase even at high concentration (~10 micro; M). Shown to inhibit the growth of U937 human leukemic monocyte lymphoma cells by inducing apoptosis and inhibiting the phosphorylation of ERK and Akt. Blocks the growth of U937 cells in nude mice and inhibits the growth of JC tumor cells in BALB/c mice without any apparent toxicity.
  • Please note that the molecular weight for this compound is batch-specific due to variable water content.
  • Catalogue Number 509106
  • Brand Family Calbiochem®
  • Synonyms SphK2 Inhibitor, K145
  • References Liu, K., et al. 2013. PLos One 8, e56471.
  • Form Off-white powder
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Quality Level MQ100
  • Primary Target Sphk2 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 4.3 µ
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 2 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

There are no questions about this product yet. Be the first to ask a question.

0 out of 5 stars
5 Star
0 %
4 Star
0 %
3 Star
0 %
2 Star
0 %
1 Star
0 %

Review this product

Tell us about your personal experience

Recently Viewed Items