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Merck - 5.30535.0001 - RPA Inhibitor, TDRL-505 - Calbiochem

  • MFR SKU: 5.30535.0001
  • ITEM #: 17953590
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ITEM #: 17953590
A cell-permeable compound that targets human Replication Protein A (RPA) and inhibits its DNA-binding activity (IC= 12.9 µM).
This listing is for 25 mg Glass bottle

Merck - 5.30535.0001 - RPA Inhibitor, TDRL-505 - Calbiochem

  • Item #: 17953590
  • MFR SKU: 5.30535.0001
  • Overview A cell-permeable quinolinyl-dihydropyrazolyl-oxobutanoic acid compound that is shown to target human Replication Protein A (RPA) via primarily the oligosaccharide/oligonucleotide-binding (OB) folds of DNA-bonding domains A & B (DBD-A/B) in the p70 subunit, effectively inhibiting its DNA-binding activity as well as that of Schizosaccharomyces pombe telemere end-binding protein Pot1 (IC 50 = 12.9 µ M and 15.7 µ M, respectively), but not Xeroderma pigmentosum group A protein (XPA) involved in the nucleotide excision repair (NER) pathway or E. coli SSB. Reported to induce cell cycle G1-arrest and decrease Annvex V - /PI - healthy cell population (by 50%; 30.8 µ M for 48 h) in H460 non-small cell lung carcinoma (NSCLC) cultures with minimal cytotoxicity against freshly isolated human PBMC. Potentiates cisplatin (Cat. No. 232120 ) and etopside (Cat. No. 341205 ) cytotoxicity in H460 cultures in a synergistic manner.
  • Catalogue Number 530535
  • Brand Family Calbiochem®
  • Synonyms Replication Protein A Inhibitor, Pot1 Inhibitor, Protection of Telemeres Protein 1 Inhibitor, TDRL505
  • References Anciano Granadillo, V.J., et al. 2010. J. Nucleic Acids 2010, 304035.
  • Shuck, S.C., and Turchi, J.J. 2010. Cancer Res. 70, 3189.
  • Form Off-white solid
  • Hill Formula CHBrClNO
  • Chemical formula CHBrClNO
  • Reversible Y
  • Quality Level MQ100
  • Primary Target Replication Protein A 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 12.9, 15.7 and 30.8 µ
  • Purity ≥ 97% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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