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Merck - 5.30959.0001 - TAZ Activity Modulator, TM-25659

  • MFR SKU: 5.30959.0001
  • ITEM #: 17953867
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ITEM #: 17953867
A cell-permeable enhancer of nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ). Does not affect the total amount of TAZ in pluripotent C3H10T1/2 cells.
This listing is for 5 mg Glass bottle

Merck - 5.30959.0001 - TAZ Activity Modulator, TM-25659

  • Item #: 17953867
  • MFR SKU: 5.30959.0001
  • Overview A cell permeable, orally bioavailable imidazol-[4, 5-b]pyridine derivative that enhances nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ) in a dose-dependent manner without affecting the total amount of TAZ in pluripotent C3H10T1/2 cells. Does not affect Ser89 phosphorylation in TAZ, but reduces tyrosine phosphorylation. Reduces PPARg levels in differentiated adipocytes and acts as a suppressor of PPARg-dependent adipocyte differentiation. Also shown to enhance RUNX2-induced osteoblast differentiation of C3H10T1/2 cells and mineralization in a dose-dependent manner. Reduces weight gain in ob/ob mice (50 mg/kg, i.p.) and attenuates bone loss in ovariectomized mice. Displays desirable pharmacokinetic properties with t 1/2 = 9.85 h.
  • Please note that the molecular weight for this compound is batch-specific due to variable water content.
  • Catalogue Number 530959
  • Brand Family Calbiochem®
  • Synonyms TM25659, TM 25659
  • References Jang, E.J., et al. 2012. Br. J. Pharmacol. 165, 1584.
  • Form Yellow powder
  • Hill Formula CHN
  • Chemical formula CHN
  • Reversible Y
  • Quality Level MQ100
  • Purity ≥ 97% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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