Merck - 5.31889.0001 - STING Agonist, 23-cGAMP - CAS 1441190-66-4 - Calbiochem

  • MFR SKU: 5.31889.0001
  • ITEM #: 17954288
  • 0 Reviews / 0 Questions
$513.50
Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 17954288
This listing is for 500 μg Glass bottle

Merck - 5.31889.0001 - STING Agonist, 23-cGAMP - CAS 1441190-66-4 - Calbiochem

  • Item #: 17954288
  • MFR SKU: 5.31889.0001
  • Overview A cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (K d = 4 nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC 50 = 20 nM). Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1. Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′, 2′-cGAMP, and 3′, 3′-cGAMP and about 75 fold greater affinity over 2′, 2′-cGAMP.
  • Please note that the molecular weight for this compound is batch-specific due to variable water content.
  • Catalogue Number 531889
  • Brand Family Calbiochem®
  • Synonyms c[G(2, 5)pA(3, 5)p], 2, 5-3, 5-cGAMP
  • References Wu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
  • Zhang, X., et al. 2013. Mol. Cell. 51, 226.
  • Wu, J., et al. 2013. Science. 339, 26.
  • CAS number 1441190-66-4
  • Form White solid
  • Hill Formula CHNOP (free acid)
  • Chemical formula CHNOP (free acid)
  • Hygroscopic Hygroscopic
  • Quality Level MQ100
  • Primary Target STING i $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target K i " value=" Biological Information"
  • br> Primary Target K<sub>i</sub> 4 nM, EC
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Light Protect from light
  • Hygroscopic Hygroscopic
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

There are no questions about this product yet. Be the first to ask a question.

0 out of 5 stars
5 Star
0 %
4 Star
0 %
3 Star
0 %
2 Star
0 %
1 Star
0 %

Review this product

Tell us about your personal experience

Recently Viewed Items