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Merck - 5.31978.0001 - ATM Inhibitor, KU 60019 - CAS 925701-46-8 - Calbiochem

  • MFR SKU: 5.31978.0001
  • ITEM #: 17954310
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ITEM #: 17954310
ATM kinase inhibitor, KU60019, is a cell permeable, potent inhibitor of ATM kinase inhibitor (IC = 6.3 nM). Has 270 & 1600-fold higher selectivity over DNA-PK and ATR kinase.
This listing is for 10 mg Glass bottle

Merck - 5.31978.0001 - ATM Inhibitor, KU 60019 - CAS 925701-46-8 - Calbiochem

  • Item #: 17954310
  • MFR SKU: 5.31978.0001
  • Overview A cell permeable thioxanthene based compound that acts as a highly potent inhibitor of Ataxia telangiectasia mutate (ATM) kinase inhibitor (IC 50 = 6.3 nM). Displays about 270 and 1600-fold greater selectivity over DNA-PK and ATR kinase (IC 50 = 1.7 and >10 µ M, respectively). Has only a trivial effect on 229 protein kinases when screened in a panel at 1 µ M level. Shown to block Ser15 phosphorylation of p53 and basal and radiation-induced Ser473 phosphorylation of Akt in glioma cells. Blocks radiation-induced DNA damage response and radiosensitizes human glioma cells (U87 and U1242) and mouse glioma stem cells and inhibits glioma cell migration, invasion, and growth. Also radiosensitizes orthotopic glioma xenografts and significantly extends the survival of mice.
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 531978
  • Brand Family Calbiochem®
  • Synonyms KU-60019, KU60019, Ataxia Telangiectasia Mutate Kinase Inhibitor
  • References Biddlestone-Thorpe, L., et al. 2013. Clin. Cancer Res. 19, 3189.
  • Golding, S., et al. 2009. Mol. Cancer Ther. 8, 2894.
  • CAS number 925701-46-8
  • Form Light beige solid
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Reversible Y
  • Quality Level MQ100
  • Primary Target ATM 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 6.3 nM
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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