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Merck - 5.33371.0001 - Acid Ceramidase Inhibitor IV, BOC - Calbiochem

  • MFR SKU: 5.33371.0001
  • ITEM #: 11575554
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ITEM #: 11575554
Acid Ceramidase Inhibitor, BOC, CAS 1644158-57-5, is a cell-permeable, potent inhibitor of acid ceramidase (IC = 79 nM against HEK293 lysosomal lysate AC activity).
This listing is for 10 mg Glass bottle

Merck - 5.33371.0001 - Acid Ceramidase Inhibitor IV, BOC - Calbiochem

  • Item #: 11575554
  • MFR SKU: 5.33371.0001
Technical Specs
  • Overview A cell-permeable, chemically and metabolically stable ( t 1/2 >5 h in aqueous buffers at pH 4.5 and 7.4; t 1/2 >2 h in murine plasma at 37 ° C) benzoxazolone carboxamide (BOC) compound that inhibits acid ceramidase (AC) activity in a potent (IC 50 = 79 nM against HEK293 lysosomal lysate AC activity) and selective manner via covalent modification of the active site Cys143, exhibiting little or no potency toward a panel of 15 enzymes, including proteases, lipoxygenases, cyclooxygenases, sPLA 2 , and monoacylglycerol lipase (67% inhibition of cathepsin D and ≤ 17.1% inhibition of the rest at 10 µ M). Culture treatment results in long-lasting (>6 h) suppression of cellular AC activity in murine macrophage-like Raw 264.7 and human colon adenocarcinoma SW403 cells (IC 50 with 3 h treatment = 400 and 825 nM, respectively), as well as built-ups of cellular AC substrates Cer(d18:0/16:0) & Cer(d18:1/16:0) in a dose-dependent manner. Intraperitoneal injection (10 mg/kg) effectively inhibits tissue AC activity in multiple organs, including lung, heart, kidney, brain hippocampus, and liver (by 70%, 60%, 44%, 40%, 35%, respectively), with good pharmacokinetic properties ( T max = 30 min, C max = 1.768 µg/mL, t 1/2 = 458 min, AUC 0-8 h = 0.31 mg·min/mL; 10 mg/kg i.p.).
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 533371
  • Brand Family Calbiochem®
  • Synonyms AC Inhibitor IV
  • References Pizzirani, D., et al. 2015. Angew. Chem. Int. Ed. Engl. 54, 485.
  • Form Off-white solid
  • Hill Formula CHFNO
  • Chemical formula CHFNO
  • Reversible N
  • Quality Level MQ100
  • Primary Target Acid ceramidase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 79 nM against HEK293 lysosomal lysate AC activity
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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