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Merck - 5.33718.0001 - NOD2 Signaling Inhibitor II, GSK717

  • MFR SKU: 5.33718.0001
  • ITEM #: 11575565
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ITEM #: 11575565
A cell-permeable diamide that selectively blocks MDP-stimulated cytokine release and downstream NF-κB and MAPK signaling pathways.
This listing is for 10 mg Glass bottle

Merck - 5.33718.0001 - NOD2 Signaling Inhibitor II, GSK717

  • Item #: 11575565
  • MFR SKU: 5.33718.0001
Technical Specs
  • Overview A cell-permeable benzimidazole diamide compound that acts as a potent, selective, reversible and muramyl dipeptide (MDP)-induced NOD2 (MDP/nucleotide-binding oligomerization domain 2)-mediated signaling inhibitor (IC 50 = 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells). Does not affect NOD1, TNFR1, or TLR-2-mediated responses. Also shown to diminish synergy between NOD2 and TLR2. Reduces MDP-stimulated IL-8, IL-6, IL-1β, and TNFα release in primary human monocytes (~5 µ M), but does not affect Pam 2 CSK 4 -stimulated IL-8 release. Due to a lack of typical activation loop/hinge-binding motif it is unlikely to act as a kinase inhibitor. NOD1 Inhibitor, Nodinitib-1 ( Cat. No. 488004 ) is also available.
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 533718
  • Brand Family Calbiochem®
  • Synonyms N-(2-(1-(2-(2, 3-Dihydro-1H-inden-5-ylamino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide, Nucleotide-binding Oligomerization Domain 2 Signaling Inhibitor II, MDP/NOD2-Mediated Signaling Inhibitor, GSK 717
  • NOD2 Signaling Inhibitor II, GSK717
  • References Rickard, D.J., et al. 2013. PLoS 8, e69619.
  • Form White solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Quality Level MQ100
  • Primary Target NOD2 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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