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Merck - 5.33756.0001 - Ac-CoA Synthase Inhibitor - CAS 508186-14-9 - Calbiochem

  • MFR SKU: 5.33756.0001
  • ITEM #: 11575566
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ITEM #: 11575566
This listing is for 25 mg Glass bottle

Merck - 5.33756.0001 - Ac-CoA Synthase Inhibitor - CAS 508186-14-9 - Calbiochem

  • Item #: 11575566
  • MFR SKU: 5.33756.0001
  • Overview A cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC 50 ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of 14 C tracer carbons from acetate into lipids (IC 50 = 6.8 µ M) and for histone acetylation (IC 50 = 5.5 µ M) in HepG2 cells.
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 533756
  • Brand Family Calbiochem®
  • Synonyms 1-(2, 3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea, N-(2, 3-di-2-Thienyl-6-quinoxalinyl)-N-(2-methoxyethyl)urea, Acyl-CoA Synthetase 2 short-chain Inhibitor; short-chain Acetyl-CoA Synthetase 2 Inhibitor, ACSS2 Inhibitor
  • References Comerford, S.A., et al. 2014. Cell. 159, 1591.
  • CAS number 508186-14-9
  • Form Yellow solid
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Reversible Y
  • Quality Level MQ100
  • Primary Target ACSS2
  • Purity ≥ 98% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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