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Merck - 5.33851.0001 - Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem

  • MFR SKU: 5.33851.0001
  • ITEM #: 11575570
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ITEM #: 11575570
A cell-permeable compound that diminishes gene expression and self-renewal in stemness high cancer cells. Blocks cancer relapse and metastasis.
This listing is for 10 mg Glass bottle

Merck - 5.33851.0001 - Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem

  • Item #: 11575570
  • MFR SKU: 5.33851.0001
Technical Specs
  • Overview A cell-permeable, bioactive, non-toxic naphthofurandione analog that blocks STAT3-driven gene transcription. Selectively diminishes gene expression and self-renewal in stemness high cancer cells. Shown to be more effective in stemness high cancer cell population (IC 50 = 142 nM) compared to regular cancer cells (IC 50 = 395 nM). Reduces spherogenesis in CD44 expressing cancer cells without affecting the colony formation in CD34 + hematopoietic stem cells. Effectively reduces the levels of Nanog, Axl, Sox-2, Klf4, survivin, c-Myc, Bmi-1, and β-catenin within a few hours following treatment. Displays broad spectrum activity against stemness high cancer cells from multiple tumors (IC 50 = 291, 432, 624, 479, 549, and 729 nM for CAOV-3, SW-626, PaCa2, SNU-475, H1975, and U87-MG, respectively). Suppresses the growth of PaCa-2 xenografts in murine models that exhibited relapse of tumor growth (20 mg/kg, i.p, q.d.) following the cessation of 41-day gemcitabine treatment. Also shown to block cancer relapse, and spleen and liver metastasis in the intrasplenic nude mouse model injected with HT29 colon cancer cells.
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 533851
  • Brand Family Calbiochem®
  • Synonyms 2-Acetyl-4H, 9H-naphtho[2, 3-b]furan-4, 9-dione, 2-Acetylnaphtho[2, 3-b]furan-4, 9-dione, Spherogenesis Blocker, BBI-608
  • Cancer Stemness Inhibitor, BBI608
  • References Li, Y., et al. 2015. Proc. Natl. Acad. Sci. USA 112, 1839.
  • CAS number 83280-65-3
  • Form Brown solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Quality Level MQ100
  • Primary Target STAT3 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 142 nM
  • Purity ≥ 97% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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