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Merck - 5.33966.0001 - LDH-A Inhibitor III, NHI-1 - CAS 1269802-68-7 - Calbiochem

  • MFR SKU: 5.33966.0001
  • ITEM #: 11575575
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ITEM #: 11575575
A cell-permeable, both NADH and pyruvate-competitive isoform A-selective LDH inhibitor. Exhibits enhanced anticancer activity under hypoxic conditions.
This listing is for 10 mg Glass bottle

Merck - 5.33966.0001 - LDH-A Inhibitor III, NHI-1 - CAS 1269802-68-7 - Calbiochem

  • Item #: 11575575
  • MFR SKU: 5.33966.0001
Technical Specs
  • Overview A cell-permeable, non-cytotoxic N-hydroxyindole (NHI) carboxylate that acts as a potent, reversible, and isoform selective inhibitor of lactic dehydrogenase (LDH) A/LDH-1. Inhibition appears to be competitive with respect to both pyruvate ( K i = 4.7 µ M) and NADH (cofactor; K i = 8.9 µ M). Acts by occupying the whole substrate pocket and part of the cofactor pocket of LDH-A. Blocks the growth of various cancer cell lines by causing an arrest at G1 phase and inducing apoptosis (IC 50 = 10.8, 10.6, 11.4, and 31.5 µ M for A2780/cOHP, MSTO-211H, NIH-H28, and H630 cells, respectively). Exhibits enhanced anticancer activity under hypoxic conditions (GI 50 = 0.90 µ M/hypoxia vs. 16.3 µ M/normoxia in LPC006 cultures) and strongly synergizes with gemcitabine (Cat. No. 504594 ).
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 533966
  • Brand Family Calbiochem®
  • Synonyms 1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-carboxylic acid, Lactate Dehydrogenase A Inhibitor III, LDH-M Inhibitor III
  • References Maftouh, M., et al. 2014. Br. J. Cancer. 110, 172.
  • Granchi, C., et al. 2011. J. Med. Chem. 54, 1599.
  • CAS number 1269802-68-7
  • Form Off-white solid
  • Hill Formula CHFNO
  • Chemical formula CHFNO
  • Reversible Y
  • Quality Level MQ100
  • Primary Target LDH-A/LDH-1 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 10.8, 10.6, 11.4, and 31.5 µ
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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