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Merck - 5.33982.0001 - Dock5 Inhibitor, C21 - CAS 54129-15-6 - Calbiochem

  • MFR SKU: 5.33982.0001
  • ITEM #: 11575577
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ITEM #: 11575577
This listing is for 50 mg Glass bottle

Merck - 5.33982.0001 - Dock5 Inhibitor, C21 - CAS 54129-15-6 - Calbiochem

  • Item #: 11575577
  • MFR SKU: 5.33982.0001
  • Overview A cell-permeable, bioavailable, non-toxic benzenesulfonamide compound that directly blocks Dock5-mediated Rac activation (k cat /K M = 7.9 x 10 4 & 9.5 x 10 4 M -1 s -1 for Rac1 & Rac2 by Dock5-DHR2, respectively) with selectivity over RhoA and Cdc42. At higher concentrations, affects Dock1 and Dock2 guanine nucleotide exchange factor activity. Shown to reversibly perturb podosome organization and inhibit osteoclastic bone degradation in a dose-dependent manner. Efficiently prevents both arthritis and metastasis-induced bone loss while preserving bone formation in several osteolytic disease mouse model (25 mg/kg, i.p. or i.v., 5 days a week for 4 weeks). Unlike alendronate (Cat. No. 126855 ), C21 does not impair bone formation.
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 533982
  • Brand Family Calbiochem®
  • Synonyms N-(3, 5-Dichlorophenyl)benzenesulfonamide
  • References Vives, V., et al. 2015. Nat. Commun. 6, 6218.
  • Vives, V., et al. 2011. J. Bone Miner. Res. 26, 1099.
  • CAS number 54129-15-6
  • Form Grey powder
  • Hill Formula CHClNOS
  • Chemical formula CHClNOS
  • Reversible Y
  • Quality Level MQ100
  • Primary Target Dock5
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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