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Merck - 5.37983.0001 - Pantothenate Kinase Inhibitor - Calbiochem

  • MFR SKU: 5.37983.0001
  • ITEM #: 11575602
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ITEM #: 11575602
Cell-permeable, potent and reversible PanK inhibitor. Blocks de novo CoA biosynthesis (IC = 0.9 µM in C3A cells).
This listing is for 10 mg Glass bottle

Merck - 5.37983.0001 - Pantothenate Kinase Inhibitor - Calbiochem

  • Item #: 11575602
  • MFR SKU: 5.37983.0001
  • Overview A cell-permeable pyridopyrazolopyrimidine based compound that acts as a potent and reversible inhibitor of pantothenate kinase (IC 50 = 70, 92 and 25 nM for PanK1β, PanK2 and PanK3, respectively; radiochemical assay, 2.5 mM [ATP]). Binds to ATP-PanK complex (apparent binding constant ~300 nM for ATP-PanK3) and exhibits mixed-type inhibition with respect to ATP and pantothenate. Shown to dose-dependently decrease [ 3 H]pantothenate incorporation into coenzyme A (apparent IC 50 = 900 nM in C3A cells) with negligible off-target toxicity (IC 50 > 56 µ M in Hep-G2 cells).
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 537983
  • Brand Family Calbiochem®
  • Synonyms 3-(2, 4-Dimethylpyrido-[2, 3:3, 4]pyrazolo[1, 5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide, PanK Inhibitor
  • Pantothenate Kinase Inhibitor
  • References Sharma, L.K., et al. 2015. J. Med. Chem. 58, 1563.
  • Form Orange solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Quality Level MQ100
  • Primary Target pantothenate kinase 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 70, 92 and 25 nM for PanK1&beta
  • Purity ≥ 97% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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