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Merck - 5.38001.0001 - T-00127-HEV1 - CAS 900874-91-1 - Calbiochem

  • MFR SKU: 5.38001.0001
  • ITEM #: 11575603
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ITEM #: 11575603
A potent & selective PI4KIIIb inhibitor that displays antienteroviral activity. Dose-dependently inhibits viral RNA replication and inactive towards HCV.
This listing is for 10 mg Glass bottle

Merck - 5.38001.0001 - T-00127-HEV1 - CAS 900874-91-1 - Calbiochem

  • Item #: 11575603
  • MFR SKU: 5.38001.0001
  • Overview A cell-permeable pyrazolopyrimidinamine derived enviroxime-like compound that displays anti-poliovirus activity with broad specificity for enteroviruses (EC 50 = 0.77, 3.38, 2.5, 1.03 & >44 µ M for PV, CVB3, HRVM, HCV 1b & HCV 2a, respectively). Dose-dependently inhibits viral RNA replication. Acts as a potent, selective, ATP-competitive and reversible inhibitor of PI4KIIIβ (IC 50 = 150 nM) with poor affinity towards PI4KIIIα & PI4KIIα (IC 50 = ~75 & ≥ 100 µ M). Shown to cause PI4KIIIβ accumulation and reduce PI4P at the Golgi apparatus. Exhibits low cytotoxicity (CC 50 > 50 µ M in HeLa cells) and attractive PK profile in mice. PI4KIIIβ Inhibitor I, BF738735 (Cat. No. 533657 ) is also available.
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 538001
  • Brand Family Calbiochem®
  • Synonyms 3-(3, 4-Dimethoxyphenyl)-2, 5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1, 5-a]pyrimidin-7-amine, PI4KIIIβ Inhibitor II
  • T-00127-HEV1
  • References Mejdrova, I., et al. 2015. J. Med. Chem. 58, In press.
  • Spickler, C., et al. 2013. Antimicrob. Agents Chemother. 57, 3358.
  • Sasaki, J., et al. 2012. EMBO J. 31, 754.
  • Arita, M., et al. 2011. J. Virol. 85, 2364.
  • CAS number 900874-91-1
  • Form Off-whte solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Quality Level MQ200
  • Primary Target PI4KIIIβ 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 150 nM for PI4KIII&beta
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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