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Merck - 5.38339.0001 - HuR-ARE Interaction Inhibitor, CMLD-2 - Calbiochem

  • MFR SKU: 5.38339.0001
  • ITEM #: 11575621
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ITEM #: 11575621
A cell-permeable compound that competitively binds to Hu antigen R (HuR; K i = 350 nM) and disrupts the interaction of HuR and adenine- and uridine-rich element (ARE) of target mRNAs.
This listing is for 10 mg Glass bottle

Merck - 5.38339.0001 - HuR-ARE Interaction Inhibitor, CMLD-2 - Calbiochem

  • Item #: 11575621
  • MFR SKU: 5.38339.0001
Technical Specs
  • Overview A cell-permeable, 2H-chromen-2-one based compound that competitively binds to Hu antigen R (HuR; K i = 350 nM) and disrupts the interaction of HuR and adenine- and uridine-rich element (ARE) of target mRNAs. Displays dose-dependent binding to full-length HuR protein and to RRM1/2 fragment. Exhibits cytotoxicity towards tumor cells and reduces their viability (IC 50 = 28.9 and 18.2 µ M for HCT-116 and MioPaCa2 cells, respectively). Has much reduced effect on normal WI-38 and CCD 841 CoN cells. Shown to induce cleavage of poly (ADP-ribose) polymerase and pro-caspase 3 (~ 50 µ M) and reduce the half-life of Bcl-2, Msi1, and XIAP in HCT-116 cells (~20 µ M) treated with actinomycin D (5 µg/ml).
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 538339
  • Brand Family Calbiochem®
  • Synonyms 5, 7-dimethoxy-8-(1-(4-methoxyphenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl)-4-phenyl-2H-chromen-2-one
  • HuR-ARE Interaction Inhibitor, CMLD-2
  • References Wu, X., et al. 2015. ACS Chem. Biol. 10, 1476.
  • Form White solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible Y
  • Quality Level MQ100
  • Primary Target HuR i $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target K i " value=" Biological Information"
  • br> Primary Target K<sub>i</sub> 350 nM for HuR binding
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20°:). Stock solutions are stable for up to months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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