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Merck - 5.38356.0001 - SRPIN803 - Calbiochem

  • MFR SKU: 5.38356.0001
  • ITEM #: 11575624
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ITEM #: 11575624
A cell-potent, bioactive, anti-angiogenic dual inhibitor of CK2 & SRPK1. Down-regulates inflammation-associated genes and inhibits choroidal neovascularization in a mouse model of AMD.
This listing is for 10 mg Glass bottle

Merck - 5.38356.0001 - SRPIN803 - Calbiochem

  • Item #: 11575624
  • MFR SKU: 5.38356.0001
  • Overview A cell-permeable, bioavailable, non-toxic thiadiazolopyrimidinone based compound that acts a potent, reversible and ATP-competitive dual inhibitor of CK2 & SRPK1 (IC 50 = 0.2 & 2.4 µ M, respectively). Displays excellent selectivity in a 306-kinase panel (% inhibition at 10 µ M = 82.5, 70.9, 59.9 & 13.7 for CK2α 1/β, CK2α 2/β, SRPK1 & SRPK2, respectively). Synergistically suppresses VEGF production in a time and dose-dependent manner and down-regulates several angiogenesis genes expression (10 µ M in ARPE-19 cells). Shown to be highly efficacious than SRPIN340 (Cat. No. 504293 ) and significantly inhibit choroidal neovascularization in a mouse model of age-related macular degeneration (intravitreous injection or topical administration).
  • Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
  • Catalogue Number 538356
  • Brand Family Calbiochem®
  • Synonyms 6-(4-Hydroxy-3-methoxybenzylidene)-5-imino-2-(trifluoromethyl)-5H-[1, 3, 4]thiadiazolo[3, 2-a]pyrimidin-7(6H)-one, SRPK1 Inhibitor II, Casein Kinase II Inhibitor XIII
  • SRPIN803
  • References Morooka, S., et al. 2015. Mol. Pharmacol. 88, 316.
  • Form Yellow solid
  • Hill Formula CHFNOS
  • Chemical formula CHFNOS
  • Reversible Y
  • Quality Level MQ100
  • Primary Target CK2, SRPK1 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 0.2 & 2.4 µ
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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