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Merck - 5.38763.0001 - 5387630001 CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem

  • MFR SKU: 5.38763.0001
  • ITEM #: 11575630
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ITEM #: 11575630
A cell-permeable, orally bioavailable, non-to x ic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cma x = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cma x = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD...
ITEM #: 11575630
A cell-permeable, orally bioavailable, non-to x ic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t1/2 = 3.5 h, Cma x = 10.8 µg/ml; i.v. 2 mg/kg: t1/2 = 5.3 h, Cma x = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
Synonyms: CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem; Compound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
Molecular Formula: C22H27N3O3S
Molecular Weight: 413.53
Linear Structural Formula: C22H27N3O3S
Purity: >=98% (HPLC)
Biochem Physiol Actions: Target IC50: 7.3 & 1.9 nM for human & mouse CD38, respectively
: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: Haffner, C.D., et al. 2015. J. Med. , 3548.Tarrago, M.G., et al. 2018 Cell. , 1081.
5387630001 CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem
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Merck - 5.38763.0001 - 5387630001 CD38 Inhibitor - CAS 1700637-55-3 - Calbiochem

  • Item #: 11575630
  • MFR SKU: 5.38763.0001
Technical Specs
  • Overview A cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC 50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; K i = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t 1/2 = 3.5 h, C max = 10.8 µg/ml; i.v. 2 mg/kg: t 1/2 = 5.3 h, C max = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).
  • Catalogue Number 538763
  • Brand Family Calbiochem®
  • Synonyms Compound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
  • References Haffner, C.D., et al. 2015. J. Med. Chem. 58, 3548.
  • Tarrago, M.G., et al. 2018 Cell. Metab. 27, 1081.
  • CAS number 1700637-55-3
  • Form White to light brown to brown solid
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Reversible Y
  • Quality Level MQ100
  • Primary Target CD38 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 7.3 & 1.9 nM for human & mouse CD38, respectively
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas
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