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Merck - 5.38769.0001 - Lipid Uptake Inhibitor, ML278 - Calbiochem

Name: Merck - 5.38769.0001 - Lipid Uptake Inhibitor, ML278 - Calbiochem
SKU: 5.38769.0001
Price: 284.0 USD
Availability: InStock

$284.00

Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 17954922
This listing is for 5 mg Glass bottle

Overview A cell-permeable, non-toxic, indolinyl-thiazole based compound that acts as a highly potent, reversible inhibitor of lipid uptake via scavenger receptor class B type I (SR-BI; IC 50 = 6 nM). Shown to block the uptake of [ 3 H] labeled cholesteryl oleate ester ([ 3 H]CE) from [ 3 H]CE-HDL (IC 50 = 7 nM). Exhibits high selectivity when tested against a panel of 67 different receptors and secondary targets (at 10 µ M). Displays excellent stability in human plasma (99% remaining after 5 h, with 94% plasma protein bound) and mouse liver microsomes (75% remaining after 1 h).
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number 538769
Brand Family Calbiochem®
Synonyms 3, 5-Dimethoxy-N-(4-(1-(2-methoxyacetyl)indolin-5-yl)thiazol-2-yl)benzamide, SR-BI inhibitor ML278
References Dockendorff, C., et al. 2015. ACS Med. Chem. Lett. 6, 375.
Form Light yellow solid

Hill Formula CHNOS
Chemical formula CHNOS
Reversible Y
Quality Level MQ100
Primary Target scavenger receptor class B type I 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"

br> Primary Target IC<sub> 50</sub> 6 nM
Purity ≥ 98% by HPLC
Cell permeable Y
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2° C to +8° C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
Packaged under inert gas Packaged under inert gas

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