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Merck - 613450-5MG - TOFA | CAS 54857-86-2 | Calbiochem | 5 MG

  • MFR SKU: 613450-5MG
  • ITEM #: 6281350
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ITEM #: 6281350
A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis.
This listing is for 5 mg Plastic ampoule

Merck - 613450-5MG - TOFA | CAS 54857-86-2 | Calbiochem | 5 MG

  • Item #: 6281350
  • MFR SKU: 613450-5MG
  • Overview A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC 50 = 4 µ M in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325 ) on food intake in fasted mice and on apoptosis in tumor cells.
  • Catalogue Number 613450
  • Brand Family Calbiochem®
  • Synonyms 5-(Tetradecyloxy)-2-furoic acid
  • References Landree, L.E., et al. 2004. J. Biol. Chem. 279, 3817.
  • Zhou, W., et al. 2003. Cancer Res. 63, 7330.
  • Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 12624.
  • Pizer, E.S., et al. 2000. Cancer Res. 60, 213.
  • Arbeeny, C.M., et al. 1992. J. Lipid Res. 33, 843.
  • Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res. 25, 831.
  • CAS number 54857-86-2
  • ATP Competitive Y
  • Form Off-white solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Acetyl-CoA carboxylase (ACC) 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 4 µ M inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Carcinogenic / Teratogenic
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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