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Merck - 614316-5MG - TLR4 Inhibitor, TAK-242 | CAS 243984-11-4 | Calbiochem | 5 MG

  • MFR SKU: 614316-5MG
  • ITEM #: 11575983
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ITEM #: 11575983
TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.
This listing is for 5 mg Glass bottle

Merck - 614316-5MG - TLR4 Inhibitor, TAK-242 | CAS 243984-11-4 | Calbiochem | 5 MG

  • Item #: 11575983
  • MFR SKU: 614316-5MG
  • Overview A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 to effectively inhibit TLR4-mediated cellular events (IC 50 = 1.8, 1.3, and 1.9 nM, respectively, against LPS-induced NO, IL-6, and TNF-α production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7 mg/kg, i.p.) induced death in mice (3 mg/kg; i.v.) in vivo . Also available as a 25 mM solution in DMSO (Cat. No. 508336 ).
  • Catalogue Number 614316
  • Brand Family Calbiochem®
  • Synonyms Ethyl-(6 R )-6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate
  • References Matsunaga, N., et al. 2011. Mol. Pharmacol. 79, 34.
  • Takashima, K., et al. 2009. Br. J. Pharmacol. 157, 1250.
  • Li, M., et al. 2006. Mol. Pharmacol. 69, 1288.
  • Yamada, M., et al. 2005. J. Med. Chem. 48, 7457.
  • CAS number 243984-11-4
  • Form White to yellowish white solid
  • Hill Formula CHClFNOS
  • Chemical formula CHClFNOS
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target TLR4
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • R Phrase R: 22
  • Harmful if swallowed.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Harmful
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-70° C). Stock solutions are stable for up to 1 year at -70° C. Use only fresh DMSO.
  • Packaged under inert gas Packaged under inert gas

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