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Merck - 616407-1MG - TACE Substrate IV, Fluorogenic | Calbiochem | 1MG

  • MFR SKU: 616407-1MG
  • ITEM #: 6281258
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ITEM #: 6281258
TACE Substrate IV, Fluorogenic
| Calbiochem | 1MG
This listing is for Each

Merck - 616407-1MG - TACE Substrate IV, Fluorogenic | Calbiochem | 1MG

  • Item #: 6281258
  • MFR SKU: 616407-1MG
  • Overview An internally-quenched fluorogenic decapeptide substrate that is useful for continuous monitoring of TACE activity and high-throughput screening of TACE inhibitors (k cat = 21.6 s -1 and substrate concentration at half the V max , S 0.5 = 342 µ M). The substrate is cleaved at Ala-Val amide bond. Acts as a poor substrate for MMP-1, MMP-9, and MMP-13. Displays better solubility in aqueous buffers.
  • Catalogue Number 616407
  • Brand Family Calbiochem®
  • Synonyms TNF-α Convertase Enzyme Substrate IV, Fluorogenic, Abz-LAQAVRSSSR-Dpa, ADAM-17 Substrate IV, Fluorogenic
  • References Jin, G., et al. 2002. Anal. Biochem. 302, 269.
  • ATP Competitive N
  • Form Yellow lyophilized solid
  • Formulation Supplied as a trifluoroacetate salt.
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Quality Level MQ100
  • Primary Target Fluorogenic decapeptide substrate that is useful for continuous monitoring of TACE activity 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> kcat = 21.6 s-1 and substrate concentration at half the Vmax, S0.5 = 342 µ M
  • Purity ≥ 95% by HPLC
  • Cell permeable N
  • Emission max.
  • Excitation max.
  • Peptide Sequence Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Protect from Moisture Protect from moisture
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.

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