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Merck - 627610-5MG - Caspase Inhibitor I (Z-VAD (OMe)-FMK) | CAS 187389-52-2 | Calbiochem | 5 MG

  • MFR SKU: 627610-5MG
  • ITEM #: 11575996
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ITEM #: 11575996
Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor.
This listing is for 5 mg Plastic ampoule

Merck - 627610-5MG - Caspase Inhibitor I (Z-VAD (OMe)-FMK) | CAS 187389-52-2 | Calbiochem | 5 MG

  • Item #: 11575996
  • MFR SKU: 627610-5MG
  • Overview A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells. Shown to enhance the freeze-thaw survival of human embryonic stem cells. When using with purified native or recombinant enzyme, pre-treatment with an esterase is required.
  • Catalogue Number 627610
  • Brand Family Calbiochem®
  • Synonyms Z-VAD (OMe)-FMK
  • References Heng, B.C., et al. 2007. Biosci. Rep. 27, 257.
  • Martin, U., et al. 2007. Apoptosis 12, 525.
  • Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.
  • Joo, C., et al. 1999. Ophthalmic Res. 31, 287.
  • McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229.
  • Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312.
  • Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735.
  • An, S. and Know, K.A. 1996. FEBS Lett. 386, 115.
  • Cain, K., et al. 1996. Biochem J. 314, 27.
  • Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266.
  • Pronk, G.J., et al. 1996. Science 271, 808.
  • Slee, E.A., et al. 1996. Biochem. J. 315, 21.
  • Chow, S.C., et al. 1995. FEBS Lett. 364, 134.
  • Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283.
  • Zhu, H., et al. 1995. FEBS Lett. 374, 303.
  • CAS number 187389-52-2
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHFNO
  • Chemical formula CHFNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells
  • Purity Single spot by TLC
  • Cell permeable Y
  • Peptide Sequence Z-Val-Ala-Asp(OMe)-CHF *
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Protect from Moisture Protect from moisture
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for 6 months at -20° C.

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