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Merck - 662035-5MG - U-73122 | CAS 112648-68-7 | Calbiochem | 5MG

  • MFR SKU: 662035-5MG
  • ITEM #: 19013105
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ITEM #: 19013105
U-73122^ ( {1-[6-((17b-3-Methoxyestra-1, 3, 5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2, 5-dione} ). Off-white solid. Inhibits agonist-induced phospholipase C activation (IC50 = 1.0 - 2.1 mM) in human platelets and neutrophils.
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Merck - 662035-5MG - U-73122 | CAS 112648-68-7 | Calbiochem | 5MG

  • Item #: 19013105
  • MFR SKU: 662035-5MG
Technical Specs
  • Overview A potent, selective, and cell-permeable inhibitor C-type phosphatidylinositol-specific phospholipases. Inhibits agonist-induced phospholipase C activation (IC 50 = 1-2.1 µ M) in human platelets and neutrophils. Inhibits ET-1 and parathyroid hormone-induced Ca 2+ transients (IC 50 = 800 nM and 500 nM, respectively). Also inhibits agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Acts as a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces (IC 50 = 50 nM). Reported to abolish T lymphoma cell invasion into fibroblast monolayers.
  • Catalogue Number 662035
  • Brand Family Calbiochem®
  • Synonyms 1-[6-((17β-3-Methoxyestra-1, 3, 5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2, 5-dione
  • References Stam, J.C., et al. 1998. EMBO J. 17, 4066.
  • Smith, R.J., et al. 1996. J. Pharmacol. Exp. Ther. 278, 320.
  • Tatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595.
  • Wang, X.D., et al. 1994. Biochim. Biophys. Acta 1223, 101.
  • Bleasdale, J.E., and Fisher, S.K. 1993. Neuroprotocols: A Companion to Methods in Neurosci. 3, 125.
  • Wu, H., et al. 1992. Biochemistry 31, 3370.
  • Yule, D.I., and Williams, J.A. 1992. J. Biol. Chem. 267, 13830.
  • Thompson, A.K., et al. 1991. J. Biol. Chem. 266, 23856.
  • CAS number 112648-68-7
  • ATP Competitive N
  • Form Off-white solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Application U-73122, CAS 112648-68-7, inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1 µ M) in human platelets and neutrophils.
  • Primary Target Agonist-induced phospholipase C activation 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 1-2.1 µ M against agonist-induced phospholipase C activation in human platelets and neutrophils; 800 nM and 500 nM, respectively, against ET-1 and parathyroid hormone-induced Ca2+ transients; 50 nM against human polymorphonuclear neutrophil adhesion
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • R Phrase R: 36/37/38
  • Irritating to eyes, respiratory system and skin.
  • S Phrase S: 26-36
  • In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
  • Wear suitable protective clothing.
  • Ship Code Ambient Temperature Only
  • Toxicity Irritant
  • Storage +15° C to +30° C
  • Do not freeze Ok to freeze
  • Special Instructions Unstable in DMSO and ethanol; reconstitute in anhydrous DMSO or ethanol just prior to use. Following reconstitution in anhydrous chloroform, aliquot into single use volumes, evaporate to dryness under a stream of nitrogen, and freeze (-20° C. Dried aliquots are stable for up to 6 months at -20° C. ); Reconstitute dried aliquots in anhydrous DMSO or anhydrous ethanol just prior to use.
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