Image is an illustration, may not reflect the exact product sold.


Other products by Merck

Merck - 666125-10MG - Urea Transporter B Inhibitor, UTBinh-14 - Calbiochem

  • MFR SKU: 666125-10MG
  • ITEM #: 13047379
  • 0 Reviews / 0 Questions
$338.00
Stock Status: SHIPS SOON (reserve your unit today)
Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 13047379
Urea Transporter B Inhibitor 10MG
Urea Transporter B Inhibitor, UTBinh-14 | Calbiochem | 10 MG
This listing is for Each

Merck - 666125-10MG - Urea Transporter B Inhibitor, UTB<sub>inh</sub>-14 - Calbiochem

  • Item #: 13047379
  • MFR SKU: 666125-10MG
  • Overview A cell-permeable triazolothienopyrimidine compound that acts as a reversible urea transporter B-selective inhibitor (IC 50 = 10.3 and 25.1 nM against urea influx using human and mouse erythrocytes, respectively) by targeting a UT-B intracellular site in a urea-competitive manner, exhibiting little effect toward UT-A1, UT-A3, AQP1, CFTR, or TMEM16A channel activities. Shown to effectively decrease maximum urinary concentration and increase urination volume from antidiuretic dDAVP-treated wild-type, but not UT-B -/- , mice (300 µg/300 µl/mouse i.p.) in vivo .
  • Catalogue Number 666125
  • Brand Family Calbiochem®
  • Synonyms 3-((4-Ethylphenyl)sulfonyl)-N-(2-thienylmethyl)thieno[2, 3-e][1, 2, 3]triazolo[1, 5-a]pyrimidin-5-amine, 3-(4-Ethylphenylsulfonyl)-N-(thiophen-2-ylmethyl)thieno[2, 3-e][1, 2, 3]triazolo[1, 5-a]pyrimidin-5-amine, UT-B Inhibitor, UTB Inhibitor, UTBinh14
  • References Anderson, M.O., et al. 2012. J. Med. Chem. 55, 5942.
  • Yao, C., et al. 2012. J. Am. Soc. Nephrol. 23, 1210.
  • Form White powder
  • Hill Formula CHNOS
  • Chemical formula CHNOS
  • Reversible Y
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target urea transporter B
  • Purity ≥ 98% by HPLC
  • Cell permeable Y
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

There are no questions about this product yet. Be the first to ask a question.

0 out of 5 stars
5 Star
0 %
4 Star
0 %
3 Star
0 %
2 Star
0 %
1 Star
0 %

Review this product

Tell us about your personal experience

Recently Viewed Items