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Merck - 681535-1MG - Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem

  • MFR SKU: 681535-1MG
  • ITEM #: 6311103
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ITEM #: 6311103
A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
This listing is for 1 mg Plastic ampoule

Merck - 681535-1MG - Withaferin A, <i>Withania somnifera</i> - CAS 5119-48-2 - Calbiochem

  • Item #: 6311103
  • MFR SKU: 681535-1MG
  • Overview A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC 50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κ B activation (IC 50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µ M) also affects AP-1 transcription and induces cell death.
  • Catalogue Number 681535
  • Brand Family Calbiochem®
  • References Mohan, R., et al. 2004. Angiogenesis 7, 115.
  • Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125.
  • Devi, P.U., et al. 1995. Cancer Lett. 95, 189.
  • Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.
  • CAS number 5119-48-2
  • ATP Competitive N
  • Form White solid
  • Hill Formula CHO
  • Chemical formula CHO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Primary Target A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> 12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation
  • Purity ≥ 94% by HPLC
  • Cell permeable Y
  • RTECS KE7288500
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Carcinogenic / Teratogenic
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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