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Merck - 681665-5MG - Wnt Agonist | CAS 853220-52-7 | Calbiochem | 5 MG

  • MFR SKU: 681665-5MG
  • ITEM #: 6280264
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ITEM #: 6280264
Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).
This listing is for 5 mg Plastic ampoule

Merck - 681665-5MG - Wnt Agonist | CAS 853220-52-7 | Calbiochem | 5 MG

  • Item #: 6280264
  • MFR SKU: 681665-5MG
  • Overview A cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC 50 > 60 µ M). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC 50 = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664 ).
  • Catalogue Number 681665
  • Brand Family Calbiochem®
  • Synonyms 2-Amino-4-(3, 4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
  • References Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
  • CAS number 853220-52-7
  • ATP Competitive N
  • Form Yellowish sticky solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Reversible N
  • Structure formula Image
  • Quality Level MQ100
  • Application Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µ M).
  • Primary Target Selective activator of Wnt signaling 50 $anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC 50 " value=" Biological Information"
  • br> Primary Target IC<sub> 50</sub> EC50 = 700 nM inducing β-catenin and TCF (T-cell fate)-dependent transcriptional activity in HEK-293T cells
  • Purity ≥ 95% by HPLC
  • Cell permeable Y
  • Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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