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Merck - 681668-5MG - Wnt Synergist, QS11 | CAS 944328-88-5 | Calbiochem | 5 MG

  • MFR SKU: 681668-5MG
  • ITEM #: 11576034
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ITEM #: 11576034
A cell-permeable purine compound that binds ARFGAPs ( K d = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor).
This listing is for 5 mg Plastic ampoule

Merck - 681668-5MG - Wnt Synergist, QS11 | CAS 944328-88-5 | Calbiochem | 5 MG

  • Item #: 11576034
  • MFR SKU: 681668-5MG
  • Overview A cell-permeable purine compound that binds ARFGAPs ( K d = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor). Shown to synergize with Wnt-3a and specifically activate the canonical Wnt/β-catenin signaling pathway both in vitro (2-, 40-, and 200-fold increase of basal transcription activity by QS11, Wnt-3a, and QS11/Wnt-3a, respectively, in a Super(8X)TOPFlash reporter assay using HEK293 cells) and in vivo (in the induction of Xenopus embryonic axis duplication). Also reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 µ M).
  • Catalogue Number 681668
  • Brand Family Calbiochem®
  • Synonyms QS11, Wnt Pathway Activator II
  • References Zhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.
  • CAS number 944328-88-5
  • Form Pale amber solid
  • Hill Formula CHNO
  • Chemical formula CHNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 95% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Regulatory Review
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 3 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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