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Merck - 681679-10MG - Wnt Pathway Inhibitor XII, 21H7 | Calbiochem | 10MG

  • MFR SKU: 681679-10MG
  • ITEM #: 11576040
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$207.50
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ITEM #: 11576040
The Iron Chelator IV, 21H7 controls the biological activity of iron-regulated enzymes. This small molecule/inhibitor is primarily used for Cancer applications.
This listing is for 10 mg Glass bottle

Merck - 681679-10MG - Wnt Pathway Inhibitor XII, 21H7 | Calbiochem | 10MG

  • Item #: 11576040
  • MFR SKU: 681679-10MG
  • Overview A cell-permeable salicylaldehyde-acylhydrazone iron chelator that is 20-times more efficient than DFO/desferrioxamine (Cat. No. 252750 ) in depleting intracellular iron in colon cancer SW480 cells. Iron chelators exert their biological activities by affecting iron-regulated enzymes and singaling events, including HIF1α transcription activation due to inhibition of PHD- (prolyl hydroxylase) mediated HIF1α degradation, as well as altered mRNA translations due to enhanced IRP (Iron Regulatory Protein) IREs (Iron Response Elements) binding. Cellular iron depletion is also reported to inhibit the growths of colorectal adenocarcinoma cultures, DLD-1 (IC 50 = 0.6 and 2.9 µ M, respectively, by 21H7 and DFO) and SW480 (IC 50 = 1.0 and 3.8 µ M, respectively, by 21H7 and DFO), as a result of Wnt signaling pathway blockage (Effective conc. = 5 µ M 21H7 or 100 µ M DFO).
  • Catalogue Number 681679
  • Brand Family Calbiochem®
  • Synonyms 6-Bromo-N-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide
  • References Song, S., et al. 2011. Cancer Res. 71, 7628.
  • Form Off-white solid
  • Hill Formula CHBrNO
  • Chemical formula CHBrNO
  • Structure formula Image
  • Quality Level MQ100
  • Purity ≥ 97% by HPLC
  • Ship Code Ambient Temperature Only
  • Toxicity Standard Handling
  • Storage +2° C to +8° C
  • Protect from Light Protect from light
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution, aliquot and freeze (-20° C). Stock solutions are stable for up to 6 months at -20° C.
  • Packaged under inert gas Packaged under inert gas

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