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Merck - 8510060100 - 8510060100 HBTU 2-(1H-Benzotriazole-1-yl)-1, 1, 3, 3-tetramethyluronium hexafluorophosphate Novabiochem(R)

  • MFR SKU: 8510060100
  • ITEM #: 11577241
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ITEM #: 11577241
TBTU and HBTU are two of the most popular in situ activation reagents used in solid phase and solution phase peptide synthesis [1-9]. These reagents offer reactivity similar to symmetrical anhydrides and BOP [1]. Couplings proceed smoothly and rates can even be enhanced by the addition of HOBt [2, 4, 5, 6]. In addition to having high reactivity, TBTU and HBTU have also been shown to limit enantiomerization during fragment condensation and during DMAP catalyzed esterification of arginine derivatives...
ITEM #: 11577241
TBTU and HBTU are two of the most popular in situ activation reagents used in solid phase and solution phase peptide synthesis [1-9]. These reagents offer reactivity similar to symmetrical anhydrides and BOP [1]. Couplings proceed smoothly and rates can even be enhanced by the addition of HOBt [2, 4, 5, 6]. In addition to having high reactivity, TBTU and HBTU have also been shown to limit enantiomerization during fragment condensation and during DMAP catalyzed esterification of arginine derivatives [3]. Comparative e x periments between HBTU and TBTU have shown that the counter ion has no influence on coupling rates or levels of enantiomerization [1].The product number for this product was previously 01-62-0010.To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
Synonyms: HBTU; 2-(1H-Benzotriazole-1-yl)-1, 1, 3, 3-tetramethylaminium he x afluorophosphate
Molecular Formula: C11H16F6N5OP
Molecular Weight: 379.24
Linear Structural Formula: C11H16F6N5OP
MDL Number: MFCD00075445
Purity: >=99.0% (HPLC)
Melting Point: 250 C
: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
8510060100 HBTU 2-(1H-Benzotriazole-1-yl)-1, 1, 3, 3-tetramethyluronium hexafluorophosphate Novabiochem(R)
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Merck - 8510060100 - 8510060100 HBTU 2-(1H-Benzotriazole-1-yl)-1, 1, 3, 3-tetramethyluronium hexafluorophosphate Novabiochem(R)

  • Item #: 11577241
  • MFR SKU: 8510060100
Technical Specs
  • 2000 mg/kg
  • Hazard Pictogram(s)
  • Hazard Statement(s) H315: Causes skin irritation.
  • H317: May cause an allergic skin reaction.
  • H319: Causes serious eye irritation.
  • H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H335: May cause respiratory irritation.
  • Precautionary Statement(s) P261: Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
  • P264: Wash skin thoroughly after handling.
  • P280: Wear protective gloves/ eye protection/ face protection.
  • P302 + P352: IF ON SKIN: Wash with plenty of water.
  • P304 + P340 + P312: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
  • P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • Signal Word Danger
  • Storage class 10 - 13 Other liquids and solids
  • WGK WGK 3 highly hazardous to water
  • Categories of danger irritant
  • Storage Store at +2° C to +8° C.
  • Declaration (railroad and road) ADR, RID Kein Gefahrgut
  • Declaration (transport by air) IATA-DGR No Dangerous Good
  • Declaration (transport by sea) IMDG-Code No Dangerous Good
  • Colour (visual) white to slight yellow to beige
  • Appearance of substance (visual) powder
  • Identity (IR) passes test
  • Assay (HPLC, area%) ≥ 99.0 % (a/a)
  • Solubility (1mmole in 2 ml DMF) clearly soluble
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