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Merck - AB742-K - Anti-Apolipoprotein B

  • MFR SKU: AB742-K
  • ITEM #: 11579927
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ITEM #: 11579927
Anti-Apolipoprotein B Antibody is an antibody against Apolipoprotein B for use in IP & WB.

Merck - AB742-K - Anti-Apolipoprotein B

  • Item #: 11579927
  • MFR SKU: AB742-K
  • UAA), resulting in the creation of a stop codon, and early translation termination.
  • Gene Symbol
  • APOB
  • apoB-48
  • FLDB
  • apoB-100
  • UniProt Number
  • P04114
  • UniProt Summary FUNCTION: SwissProt: P04114 # Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
  • SIZE: 4563 amino acids; 515563 Da
  • SUBCELLULAR LOCATION: Secreted.
  • PTM: Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.
  • DISEASE: SwissProt: P04114 # Defects in APOB are a cause of familial hypobetalipoproteinemia (FHBL) [MIM:107730]. FHBL is a genetically heterogeneous autosomal co-dominant disorder, associated with reduced plasma concentrations of apoB, LDL and VLDL. Heterozygotes for FHBL are usually asymptomatic with LDL cholesterol and apoB- 100 concentrations less than 50% of those in normal plasma. Homozygotes have extremely low plasma LDL cholesterol and apoB-100 concentrations, and clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia [MIM:200100]. & Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB) [MIM:144010]. FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. & Defects in APOB associated with defects in other genes (polygenic) can contribute to :SwissProt: P04114 ## Contains 1 vitellogenin domain.
  • Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Storage Conditions Maintain at -20° C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
  • Material Size Bulk packaging. Please inquire.

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