Merck - ABS1008 - ABS1008, Anti-phospho Glucocorticoid Receptor (Ser134) Antibody from rabbit, purified by affinity chromatography

ITEM #: 11556373
Glucocorticoid receptor (UniProt P04150; also known as GR, Nuclear receptor subfamily 3 group C member 1) is encoded by the NR3C1 (also known as GCCR, GCR, GCRST, GRL) gene (Gene ID 2908) in human. Glucocorticoid receptor is widely e x pressed in almost all cell types and regulates genes that control development, metabolism, and immune response upon binding glucocorticoids. Hormone-bound GR translocates from the cytoplasm to the nucleus where it regulates gene transcriptions by binding to glucocorticoid response elements (GREs) or by interacting with various transcription factors. Alternatively, hormone-bound GR can represses gene transcriptions by blocking the nuclear translocation of transcription factors. BDNF-stimulated TrkB activation is shown to induce GR phosphorylation at Ser155 and Ser287 in primary rat cortical neurons (equivalent to human GR Ser134 and Ser267), resulting in enhanced GR transcription activity. GR is composed of an N-terminal modulating domain (a.a. 1-420), a DNA-binding domain (a.a. 421-486), and a C-terminal ligand-binding domain (a.a. 528-777).
Synonyms: Glucocorticoid receptor, Ser134-phosphorylated, GR, Ser134-phosphorylated, Nuclear receptor subfamily 3 group C member 1, Ser134-phosphorylated
Application: Western Blotting Analysis: A representative lot detected BDNF-induced Ser155 phosphorylation of endogenous GR in primary rat cortical neurons (Lambert, W.M., et al. (2013). Mol. Cell. Biol. 33(18):3700-3714).Western Blotting Analysis: A representative lot detected BDNF-induced Ser155 phosphorylation of e x ogenously e x pressed wild-type, but not S155A mutant, rat GR in transfected HEK293TrkB cells (Lambert, W.M., et al. (2013). Mol. Cell. Biol. 33(18):3700-3714).
Other Notes: Concentration: Please refer to lot specific datasheet.
ABS1008, Anti-phospho Glucocorticoid Receptor (Ser134) Antibody from rabbit, purified by affinity chromatography
This listing is for Each