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Merck - CC1100 - GM6001 MMP Inhibitor Powder; 10 mg

  • MFR SKU: CC1100
  • ITEM #: 11557807
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ITEM #: 11557807
The GM6001 MMP Inhibitor Powder controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Biochemicals applications.

Merck - CC1100 - GM6001 MMP Inhibitor Powder; 10 mg

  • Item #: 11557807
  • MFR SKU: CC1100
Technical Specs
  • 95% pure by HPLC; some batches can be brown when hydrated; brown color does not influence inhibition ability; in solution GM6001 ranges from clear to brown.
  • Entrez Gene Number
  • NM_002421.2
  • Entrez Gene Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
  • Gene Symbol
  • MMP1
  • CLG
  • MMP-1
  • CLGN
  • EC 3.4.24.7 [Contains: 22 k. Da interstitial collagenase
  • 27 k. Da interstitial collagenase].
  • Protein Target Interstitial collagenase
  • Uni. Prot Number
  • P03956
  • P08253
  • P08254
  • P22894
  • P22894
  • Uni. Prot Summary FUNCTION: Swiss. Prot: P22894 # Can degrade fibrillar type I, II, and III collagens.
  • COFACTOR: Binds 3 calcium ions per subunit. & Binds 2 zinc ions per subunit.
  • SIZE: 467 amino acids; 53412 Da
  • SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Stored in intracellular granules.
  • TISSUE SPECIFICITY: Neutrophils.
  • DOMAIN: Swiss. Prot: P22894 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.
  • Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
  • Storage Conditions Maintain lyophilized form at 2-8º C for up to one year from date of receipt. If reconstitution is in DMSO, material is soluble to at least 400 mg/mL and storage is recommended in usable aliquots at -20 º C. Avoid repeated freeze/thaw cycles. If reconstituting in aqueous solution, store short term in undiluted aliquots at 2-8º C. See stability information for further detail.
  • Material Size 10 mg
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