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Merck - PF023-5UG - MMP-2, Active, Human, Recombinant, Mouse Cells

Name: Merck - PF023-5UG - MMP-2, Active, Human, Recombinant, Mouse Cells
SKU: PF023-5UG
Price: 530.85 USD
Availability: InStock

$530.85

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Average lead time for this brand: 2-3 weeks. Specific products may vary.

ITEM #: 4147739
ACTIVE MMP-2 ENZYME 5UG
This listing is for Each

Overview Full-length, recombinant, human pro-MMP-2 expressed in mouse cells that is subsequently activated by APMA. APMA is removed through a desalting column. The substrate specificity for MMP-2 includes collagen (types IV, V, VII, and X), elastin, and gelatin (type I). The presence of TIMP-2 inhibitor prevents degradation of the MMP-2 C-terminal regulatory domain. TIMP-2 is also an inhibitor of proteolysis and will inhibit the activity of the enzyme. Useful for immunoblotting, substrate cleavage assay and zymography.
Catalogue Number PF023
Brand Family Calbiochem®
Synonyms Gelatinase A, Active Matrix Metalloproteinase 2
References Liepnisch, E., et al. 2003. J. Biol. Chem. 278, 25982.
Parsons, S.L., et al. 1997. Br. J. Surg. 84, 160.
Backstrom, J.R., et al. 1996. J. Neuro. 16, 7910.
Lim, G.P., et al. 1996. J. Neurochem. 67, 251.
Xia, T., et al. 1996. Biochim. Biophys. Acta 1293, 259.
Chandler, S., et al. 1995 Neuroscience Letters 201, 226.
Sang, Q.X., et al. 1995. Biochim. Biophys. Acta 1251, 99.
Kenagy, R.D. and Clowes, A.W. 1994. In Inhibition of Matrix Metalloproteinases: Therapeutic Potential. Greenwald, R.A. and Golub L.M., Eds, 465.
Zempo, N., et al. 1994. J. Vasc. Surg. 20, 217.
Birkedal-Hansen, H. 1993. J. Periodontol. 64, 484.
Stetler-Stevenson, W.G., et al. 1993. FASEB J. 7, 1434.
Delaisse, J-M. and Vaes, G. 1992. In Biology and Physiology of the Osteoclast. B.R. Rifkin and C.V. Gay, Eds., 290.

Jeffrey, J.J. 1992. In Wound Healing: Biochemical and Clinical Aspects. R.F. Diegelmann and W.J. Lindblad, Eds., 194.
Jeffrey, J.J. 1991. Semin. Perinatol. 15, 118.
Liotta, L.A., et al. 1991. Cell 64, 327.
Harris, E. 1990. N. Engl. J. Med. 322, 1277.
Activity ΔΑ/hour/µg protein: ≥ 7.0 in standard thiopeptolide hydrolysis assays.
EC number 3.4.24.24
Form Liquid
Formulation In 50 mM HEPES, 10 mM CaCl, 20% glycerol, 0.005% BRIJ ® -35 Detergent, pH 7.5.
Preservative None
Quality Level MQ100
Purity ≥ 90% by SDS-PAGE; contains 9% TIMP-2
Concentration Label Please refer to vial label for lot-specific concentration
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70° C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special Instructions Following initial use, aliquot into siliconized vials and freeze (-70° C).

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