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Merck - PF125-50UG - BACE1, HisTag, Human, Recombinant, NSO Cells

  • MFR SKU: PF125-50UG
  • ITEM #: 6281168
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ITEM #: 6281168
Recombinant, human BACE-1 (amino acids 1-460) fused at the C-terminus to a His•Tag ® sequence and expressed in NSO cells. Supplied as a mixture of ~68-70 kDa proenzyme and ~65-67 kDa mature enzyme.
This listing is for 50 μg Plastic ampoule

Merck - PF125-50UG - BACE1, HisTag, Human, Recombinant, NSO Cells

  • Item #: 6281168
  • MFR SKU: PF125-50UG
Technical Specs
  • Overview Recombinant, human BACE-1 (amino acids 1-460) fused at the C-terminus to a His• Tag ® sequence and expressed in NSO cells. Supplied as a mixture of the ~68-70 kDa proenzyme and the ~65-67 kDa mature enzyme. BACE-1 is an aspartic protease that has been shown to cleave the amyloid precursor protein β site in the brain to generate the amyloid β peptide. MW: ~65-70 kDa under reducing conditions.
  • Catalogue Number PF125
  • Brand Family Calbiochem®
  • Synonyms Human β-Secretase
  • References Ermolieff, J. et al. 2000. Biochemistry 39, 12450.
  • Lin, X. et al. 2000. Proc. Natl. Acad. Sci. USA 97, 1456.
  • Sinha, S. et al. 1999. Nature 402, 537.
  • Vassar, R. et al. 1999. Science 286, 735.
  • Yan, R. et al. 1999. Nature 402, 533.
  • Activity ≥ 1 pmol/min/µg as measured by the cleavage of 10 µ M MCA-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(DNP)-Arg-Arg-NH fluorescent substrate using 100 ng BACE-1 in 0.1 M sodium acetate (pH 4.0) at room temperature.
  • Form Lyophilized
  • Formulation Lyophilized from sterile-filtered PBS.
  • Preservative None
  • Quality Level MQ100
  • Purity ≥ 90% by SDS-PAGE
  • Specific Activity ≥ 1 pmol/min/µg protein
  • Contaminants Endotoxin: ≤ 1 EU/µg BACE-1
  • Ship Code Blue Ice Only
  • Toxicity Standard Handling
  • Storage -20° C
  • Do not freeze Ok to freeze
  • Special Instructions Following reconstitution refrigerate (4° C) for short-term storage or aliquot and freeze (-20° C or -70° C) for long-term storage. Stock solutions are stable for up to 1 month at 4° C or for up to 4 months at -20° C or -70° C. Avoid freeze/thaw cycles of solutions.
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