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Merck - SCC064 - SCC064 LX-2 Human Hepatic Stellate Cell Line

  • MFR SKU: SCC064
  • ITEM #: 11569523
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ITEM #: 11569523
Hepatic stellate cells are a major cell type responsible for liver fibrosis following their activation into fibrogenic myofibroblast-like cells in diseases such as chronic alcoholism, hepatitis B and C, fatty liver disease, obesity and diabetes. There is an increasing need for renewable cell culture models that faithfully recapitulate their in vivo phenotype, particularly for human -2 was generated by immmortalization of primary human hepatic stellate cells with the SV40 large T antigen followed...
ITEM #: 11569523
Hepatic stellate cells are a major cell type responsible for liver fibrosis following their activation into fibrogenic myofibroblast-like cells in diseases such as chronic alcoholism, hepatitis B and C, fatty liver disease, obesity and diabetes. There is an increasing need for renewable cell culture models that faithfully recapitulate their in vivo phenotype, particularly for human -2 was generated by immmortalization of primary human hepatic stellate cells with the SV40 large T antigen followed by selective culture of early passaged cells in low serum media conditions. Immortalized LX-2 was established by Xu et al to overcome issues of culture variability and to provide a stable and unlimited source of human hepatic stellate cells that are homogeneous. These cell lines have been e x tensively characterized and retain key features of cytokine signaling, neuronal gene e x pression, retinoid metabolism, and fibrogenesis, making them highly suitable for culture based studies of human hepatic fibrosis.
Synonyms: HSC, Perisinusoidal cells, Ito cells, Hepatic lipocytes, Hepatic pericytes
Application: Research Category. Infectious Diseases. Inflammation & Immunology. Stem Cell Research
SCC064 LX-2 Human Hepatic Stellate Cell Line
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Merck - SCC064 - SCC064 LX-2 Human Hepatic Stellate Cell Line

  • Item #: 11569523
  • MFR SKU: SCC064
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