Merck - SCT063 - SCT063, BioTracker Si-DMA Singlet Oxygen Live Cell Dye Live cell imaging dye for singlet oxygen (1O2) localized to mitochondria. Singlet oxygen is important in the field of cancer therapy, photodynamic medicine and other skin treatments.

ITEM #: 17972261
Singlet o x ygen (1O2) is one of the reactive o x ygen species (ROS). Singlet o x ygen is known to be a cause of spots and wrinkles of the skin due to its very strong o x idizing potential. However, the reactivity of singlet o x ygen, if controlled, can be used for therapy. In the field of cancer research and therapy, singlet o x ygen is being used for photodynamic therapy (PDT), an emerging anticancer treatment using photoirradiation and Si-DMA Singlet O x ygen Live Cell Dye is a novel far-red fluorescence probe that is composed of silicon-containing rhodamine and anthracene moieties as a chromophore and a singlet o x ygen reactive site, respectively. In the presence of singlet o x ygen, fluorescence of Bio. Tracker Si-DMA live cell dye increases 17 times due to endopero x ide formation at the anthracene moiety. The dye is highly selective to singlet o x ygen, among seven different reactive o x ygen species (1O2, O2-, H2O2, HOCL-, RCO-, OH-, NO). Among three different intracellular photosensitizers, Bio. Tracker Si-DMA selectively detects the 1O2 that is generated by 5-aminolevulinic acid-derived protoporphyrin IX, localized in mitochondria. On the other hand, mitochondria-targeted Killer. Red and lysosomal porphyrins could not induce fluorescence change in the Properties. Absorbance: 640 nm. Emission: 670 nm
Synonyms: Live cell imaging probe
Purity: >=98% (H-NMR); >=98% (HPLC); >=98% (LC/MS); >=98% (elemental analysis)
Application: Research Sub Category. Live Cell Dye
Other Notes: Concentration: Please refer to lot specific datasheet.
SCT063, Bio. Tracker Si-DMA Singlet Oxygen Live Cell Dye Live cell imaging dye for singlet oxygen (1O2) localized to mitochondria. Singlet oxygen is important in the field of cancer therapy, photodynamic medicine and other skin treatments.
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