Merck - SCT131 - SCT131, BioTracker 510 Green C1 Synaptic Dye Live cell imaging synaptic dye that detects neural synaptic activitiy at neuromuscular junctions and synapses.

ITEM #: 18492751
Bio. Tracker synaptic dyes are a series of fluorescent cationic styryl dyes developed to follow synaptic activities at neuromuscular junctions or synapses. These dyes typically have a lipophilic tail at one end and a highly hydrophilic at the other end. In the presence of cells or tissue preparations, the dyes partition between the aqueous phase, where the dyes are virtually non-fluorescent, and the outer leaflet of the cell surface membranes, where the dyes insert the lipophilic end into the membranes and become intensely fluorescent. During endocytosis following nerve stimulation, the dyes become trapped inside the vesicles. Thus, after washing off the dyes on the cell surface, the fluorescent signal is proportional to the number of newly formed vesicles. On the other hand, during e x ocytosis, the dyes are released from the vesicles along with neurotransmitters, causing a decrease in fluorescent signal. As a result, the change in fluorescent intensity reflects the amount of endocytosis/e x ocytosis or synaptic 510 Green C1 Synaptic Dye has the shortest (one-carbon) lipophilic tail and is the most water soluble of the nerve terminal dye series and has the slowest on-rate and the fastest off- Properties. Absorbance (MeOH): 510 nm. Emission (MeOH): 625 nm. Absorbance (Membranes): 480 nm. Emission (Membranes): 600 nm
Synonyms: Live cell imaging probe
Application: Research Sub Category. Live Cell Dye
SCT131, Bio. Tracker 510 Green C1 Synaptic Dye Live cell imaging synaptic dye that detects neural synaptic activitiy at neuromuscular junctions and synapses.
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