MP Biomedicals - 03OPH10901 - Q-VD-Oph 1mg

ITEM #: 5122214
The novel Q-VD-OPH compound synthesized using proprietary technology is an irreversible caspase inhibitor specifically designed for in-vivo Q-VD-OPH irreversibily binds to activated Caspases to block apoptosis. Apoptosis is a physiological form of cell death, which plays an important role in embryogenesis, cellular homoestasis, tissue atrophy , and removal damaged and mutated cells. Caspases, which act as molecular chainsaws, are the central components of apoptosis response. Caspases are Cysteine proteases that cleave after aspartate residue in their substrates. At least 7 of 14 known mammalian caspases have important role in apoptosis The "OPH" trap with its superior potency, proven cell permeability and minimal to x icity provides an e x ceptional alternative to the Fluoromethylketone family of inhibitors. These two types of compounds may form the basis for important new drug candidates for a wide variety of disease targets.
Q-VD-OPh is a cell-permeable, irreversible inhibitor of caspase activity (Philipp J. Jost, 2009). The "OPH" trap provides these important features: Nonto x ic (preliminary study showed no evidence of to x icity in mice injected intraperitoneally with more than 1000 mg/kg) and Potency (Our new caspase inhibitors show significant improvement in potency. IC50 values against purified caspases are now in the nanomolar range. In an in vitro cell based assay, greater than 90% inhibition of apoptosis was achieved). Note: Optimal dilutions should be determined by the laboratory for each specific applications.
Grade : HPLC >95%
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