Sigma Aldrich / Merck - Y0503-5MG - Y-27632 dihydrochloride

ITEM #: 16087801
Synonym: ( R )-(+)- trans - 4- (1- Aminoethyl) - N- (4- Pyridyl) cyclohexanecarboxamide dihydrochloride Y-27632 dihydrochloride is an effective bronchodilator and improves lung resistance (RL) induced by antigen and acetylcholine. Y-27632 controls neutrophil migration and lung edema and may be a potential drug for treating acute lung injury.
Y-27632 dihydrochloride has been used: • as a medium supplement in pancreatic ductal adenocarcinoma organoid culture • in the inhibition of Ras homolog gene family (Rho) kinase in mouse embryonic stem cells • in the inhibition of Rho-associated protein kinase (ROCK) in human embryonic stem cells and human induced pluripotent stem cells (iPSCs)
1, 5 mg in glass bottle
Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. K i = 140 nM for p160 ROCK . Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.
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Sold under license from Mitsubishi Pharma Corporation
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